Journal
SCIENCE
Volume 299, Issue 5611, Pages 1391-1394Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1081331
Keywords
-
Categories
Funding
- NHGRI NIH HHS [R01-HG02362-01] Funding Source: Medline
- NHLBI NIH HHS [HL66728] Funding Source: Medline
Ask authors/readers for more resources
Nonhuman primates represent the most relevant model organisms to understand the biology of Homo sapiens. The recent divergence and associated overall sequence conservation between individual members of this taxon have nonetheless largely precluded the use of primates in comparative sequence studies. We used sequence comparisons of an extensive set of Old World and New World monkeys and hominoids to identify functional regions in the human genome. Analysis of these data enabled the discovery of primate-specific gene regulatory elements and the demarcation of the exons of multiple genes. Much of the information content of the comprehensive primate sequence comparisons could be captured with a small subset of phylogenetically close primates. These results demonstrate the utility of intraprimate sequence comparisons to discover common mammalian as well as primate-specific functional elements in the human genome, which are unattainable through the evaluation of more evolutionarily distant species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available