Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 463, Issue 1-3, Pages 199-216Publisher
ELSEVIER
DOI: 10.1016/S0014-2999(03)01282-2
Keywords
amygdala; bed nucleus of the stria terminalis; fear; anxiety; stress; CRF (corticotropin releasing hormone)
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Funding
- NIMH NIH HHS [MH 52384, MH 57250, MH 59906, MH 58922, MH 47840] Funding Source: Medline
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The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. Despite its strategic anatomical position, initial attempts to implicate the bed nucleus of the stria tenninalis in conditioned fear were largely unsuccessful. Recent studies have shown, however, that the bed nucleus of the stria tenninalis does participate in certain types of anxiety and stress responses. In this work, we review these findings and suggest from the emerging pattern of evidence that, although the bed nucleus of the stria terminalis may not be necessary for rapid-onset, short-duration behaviors which occur in response to specific threats, the bed nucleus of the stria terminalis may mediate slower-onset, longer-lasting responses that frequently accompany sustained threats, and that may persist even after threat termination. (C) 2003 Elsevier Science B.V. All rights reserved.
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