Journal
JOURNAL OF PINEAL RESEARCH
Volume 34, Issue 2, Pages 134-142Publisher
WILEY
DOI: 10.1034/j.1600-079X.2003.00020.x
Keywords
Alzheimer's disease; melatonin; metal ions; oxidative stress
Categories
Ask authors/readers for more resources
Melatonin is an efficient protector against hydrogen peroxide(H2O2 )-induced lipid peroxidation and acts in a concentration-dependent manner. Hydrogen peroxide is rather a water stable molecule which is able to cross the cell membrane much better than some important free radicals such as superoxide anion, and consequently its local production can lead to significant spread by diffusion. In this paper we report data regarding some biochemical properties of melatonin as well as the chemical characterization of the major product formed from the interaction between melatonin and H-2 O-2 (N-1 -acetyl-N-2 -formyl-5-methoxykynuramine) that are consistent with previous data reported by other authors. The effect of melatonin on catalase, glutathione peroxidase and superoxide dismutase in in vitro and in vivo experiments is also reported.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available