Journal
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
Volume 13, Issue 10, Pages 5143-5148Publisher
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
DOI: 10.7314/APJCP.2012.13.10.5143
Keywords
Breast cancer; diabetes; 8-OhdG; HIF-1 alpha levels
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Objective: The aim was to investigate indicators related to DNA damage and cancer pathogenesis in Type II diabetes cases with breast cancer. It was planned to evaluate the relationship between these markers with oral antidiabetic drugs. Research Design and Methods: Fourty patients and 10 healthy individuals were included in the study. HIF-1 alpha and 8-OHdG are examined in blood samples taken from these individuals with an ELISA Kit. Statistical analysis of data was performed with 95% confidence using Windows package program SPSS 15.0. Results: HIF-1 alpha parameters were found to be meaningfully higher in the patient group than the controls in both pretreatment and posttreatment periods (p<0.05). No significant differences in terms of 8-OHdG between patients and controls. However, posttreatment serum HIF-1 alpha ve 8-OHdG levels was found lower than pretreatment levels in patients receiving metformin, but not with pioglitazone. Conversely, serum 8-OHdG levels decreased significantly in these patients. When patients were evaluated according to the treatment groups (pioglitazone vs. metfformin) no significant differences in terms of serum HIF-1 alpha and 8-OHdG levels between treatment groups. Conclusions: HIF-1 alpha levels decreased significantly in the patient group receiving metformin. However, there was no significant difference in terms of HIF-1 alpha levels in the patients receiving pioglitazone.
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