Journal
TRENDS IN NEUROSCIENCES
Volume 26, Issue 3, Pages 119-122Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(03)00022-5
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G-protein-coupled receptors generate signals that promote gene transcription through the 'transactivation' of receptor tyrosine kinases; (RTKs) and activation of the mitogen-activated protein kinase (MAPK) cascade - a process that involves RTK autophosphorylation and endocytosis. Pioneering work now suggests that D4-dopamine-receptor-mediated transactivation of the platelet-derived growth factor 0 receptor has immediate effects on synaptic neurotransmission via Ca2+-dependent inactivation of NMDA receptors. The demonstration of a physiological role for RTK transactivation in the CNS provides novel opportunities for understanding how aberrant dopamine signalling might contribute to cognitive and attention deficits associated with schizophrenia and attention-deficit hyperactivity disorder.
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