Journal
DEVELOPMENT
Volume 130, Issue 6, Pages 1059-1068Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.00270
Keywords
habenula; epithalamus; epiphysis; pineal organ; brain laterality
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Funding
- NCRR NIH HHS [R01 RR15402] Funding Source: Medline
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The dorsal diencephalon (or epithalamus) of larval zebrafish displays distinct left-right asymmetries. The pineal complex consists of the pineal organ anlage and an unpaired, left-sided accessory organ-the parapineal. The neighboring brain nuclei, the left and right dorsal habenulae, show consistent differences in their size, density of neuropil and gene expression. Mutational analyses demonstrate a correlation between the left-right position of the parapineal and the laterality of the habenular nuclei. We show that selective ablation of the parapineal organ results in the loss of habenular asymmetry. The left-sided parapineal therefore influences the left-right identity of adjacent brain nuclei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
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