Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 3, Pages 297-302Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(03)00016-3
Keywords
4-aryloxymethyl coumarins; 4-(2'-benzo[b] furanyl) coumarins; anti-inflammatory activity
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4-(Bromomethyl) coumarins 1 have been reacted with vanillins, 2 and 2A to obtain the corresponding ethers 3 and 5. Ethers 3 have been reacted with ethyl cyanoacetate to obtain the unsaturated esters 4. Ethers 5 have been converted to the corresponding 4(2'-benzo[b] furanyl) coumarins 6 by an intramolecular aldol condensation. Eight compounds have been screened for their anti-inflammatory activity. Out of these the 5,6-benzo-4-2'-benzo[b]furanyl) coumarin (6c) and the aryloxymethyl coumarin (4) with p formyl group were found to be most active. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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