Journal
TRENDS IN IMMUNOLOGY
Volume 24, Issue 3, Pages 104-108Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(03)00022-X
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The TCL1 (T-cell leukemia 1) protooncogene is highly expressed in many human B-cell leukemias and two recent papers show that TCL1 overexpression causes rapid development of B-cell lymphomas in mice. Other recent work showing that the TCL1 protein enhances the activation of the pro-survival kinase Akt has revealed a potential mechanism underlying the development of B-cell leukemias and raised new questions about the regulation of Akt.
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