Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 3, Pages 313-318Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(02)01447-2
Keywords
thiazoles; arylthiourea; arylaldehydethiosemicarbazone; arylfurfuraldehyde thiosemicarbazone; antibacterial activity; anti-inflammatory activity
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A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, H-1-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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