Journal
PHYTOCHEMISTRY
Volume 62, Issue 6, Pages 901-909Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(02)00711-2
Keywords
Taxus x media cv. Hicksii; Taxus cuspidata; Taxaceae; yew; metabolomics; metabolic profiling; taxane diterpenoids; taxoids; paclitaxel; Taxol (R)
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Funding
- NCI NIH HHS [CA70735, CA55254] Funding Source: Medline
- NCRR NIH HHS [RR11981] Funding Source: Medline
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Cells from suspension cultures of Taxus cuspidata were extracted with pentane as a source of relatively non-polar taxoids. Of the 13 taxoids identified in this fraction, eight were oxygenated at C-14 and two had not been previously described. These taxoids, along with existing taxoid standards, were employed to profile the metabolites of Taxus x media cv. Hicksii cell suspension cultures induced with methyl jasmonate to produce paclitaxel (Taxol(R)). The majority of the taxoid metabolites produced in these induced cultures were oxygenated at C-13, and not C-14. (C) 2003 Elsevier Science Ltd. All rights reserved.
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