Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 25, Issue 2-4, Pages 173-183Publisher
KARGER
DOI: 10.1159/000072266
Keywords
5-hydroxytryptamine; 5-HT receptor; transporter; 5-HT1B; 5-HT transporter; VMAT2; MAO-A knockout; pattern formation; cortex; barrel
Categories
Funding
- NIMH NIH HHS [U54 MH066418] Funding Source: Medline
- Telethon [GGP02019] Funding Source: Medline
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Monoaminergic neurotransmitter systems appear early during embryogenesis, suggesting that they could play important roles in brain development. Accumulated evidence indicates that serotonin (5-hydroxytryptamine, 5-HT) regulates neural as well as nonneural development, including early aspects of embryonic development, differentiation of neuronal progenitors, and morpho-genesis of the craniofacial region, heart and limb. Recent studies using monoamine oxidase-A (MAO-A), 5-HT transporter, vesicular monoamine transporter-2 (VMAT2) and 5-HT1B receptor single, double and triple knockout mice have provided evidence that the serotonergic system plays important roles in barrel field formation in the developing somatosensory cortex. Here we review evidence from these genetic mouse models and, based on the accumulated evidence, propose a testable model for future studies of mechanisms underlying serotonergic regulation of cortical development. Copyright (C) 2003 S. Karger AG, Basel.
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