Journal
ASIAN JOURNAL OF CHEMISTRY
Volume 26, Issue 4, Pages 1077-1080Publisher
ASIAN JOURNAL OF CHEMISTRY
DOI: 10.14233/ajchem.2014.15865
Keywords
Pechmann cyclization; 4-Bromomethyl coumarin; 4-(Coumaryl) alanine; Antimicrobial activity; Cup plate method
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4-Bromomethyl coumarins (3) when reacted with diethyl acetamidomalonate (4) in presence of sodium hydride afforded the intermediate compounds 5. Compounds 5 on hydrolysis with 48 % HBr resulted in hydrobromide salt of corresponding alanine derivatives (6). Free alanines (7) were obtained by neutralizing with ammonia solution. The resulting alanine derivatives (7) were characterised by IR, NMR and mass spectroscopic techniques and further screened for their antimicrobial activity.
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