Journal
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Volume 284, Issue 3, Pages E549-E556Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00379.2002
Keywords
lipoprotein; fatty acids; lipolysis
Categories
Funding
- NCRR NIH HHS [RR-00036] Funding Source: Medline
- NICHD NIH HHS [HD-01459] Funding Source: Medline
- NIDDK NIH HHS [DK-56341, DK-59534, DK-37948] Funding Source: Medline
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The effects of obesity and weight loss on lipoprotein kinetics were evaluated in six lean women [body mass index (BMI): 21 +/- 1 kg/m(2)] and seven women with abdominal obesity (BMI: 36 +/- 1 kg/m(2)). Stable isotope tracer techniques, in conjunction with compartmental modeling, were used to determine VLDL-triglyceride (TG) and apolipoprotein B-100 (apoB-100) secretion rates in lean women and in obese women before and after 10% weight loss. VLDL-TG and VLDL-apoB-100 secretion rates were similar in lean and obese women. Weight loss decreased the rate of VLDL-TG secretion by similar to40% (from 0.41 +/- 0.05 to 0.23 +/- 0.03 mumol(.)kg fat-free mass(-1).min(-1); P < 0.05). The relative decline in VLDL-TG produced from nonsystemic fatty acids, derived from intraperitoneal and intrahepatic TG, was greater (61 +/- 7%) than the decline in VLDL-TG produced from systemic fatty acids, predominantly derived from subcutaneous TG (25 8%; P < 0.05). Weight loss did not affect VLDL-apoB-100 secretion rate. We conclude that weight loss decreases the rate of VLDL-TG secretion in women with abdominal obesity, primarily by decreasing the availability of nonsystemic fatty acids. There is a dissociation in the effect of weight loss on VLDL-TG and apoB-100 metabolic pathways that may affect VLDL particle size.
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