Journal
CANCER CELL
Volume 3, Issue 3, Pages 297-302Publisher
CELL PRESS
DOI: 10.1016/S1535-6108(03)00054-0
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Funding
- NCI NIH HHS [5R01-CA78544, R43 CA86765-01, R01 CA81152-04, OIG-CA39829, 1R21-CA81674, P30 CA008748, 5P50-CA68425-05] Funding Source: Medline
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Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a series of breast cancer samples harboring amplification of this region and determined that KCNK9 is the sole overexpressed gene within the amplification epicenter. KCNK9 encodes a potassium channel that is amplified from 3-fold to 10-fold in 10% of breast tumors and overexpressed from 5-fold to over 100-fold in 44% of breast tumors. Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.
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