Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 3, Pages 357-363Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0204500
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Funding
- FIC NIH HHS [1 UO1TW01021-01] Funding Source: Medline
- NINDS NIH HHS [U54-NS39408-04] Funding Source: Medline
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A new chemical study of the hexane extract of the gorgonian Briareum polyanthes collected in Puerto Rico afforded 10 new diterpenes of the eunicellin class, briarellins 1-9 and polyanthellin A (10), along with the known diterpene briarellin D (11). The structures and relative stereochemistry of metabolites 1-10 were assigned on the basis of NMR studies, chemical methods, and comparisons to the spectral properties of 11. A reassessment of prior structural assignment for briarellin A and two known sclerophytin-type diterpenes, 13 and 14, is proposed. Antimalarial tests on 1-6 and 8-12 indicated that they were active against Plasmodium falciparum.
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