Journal
BIOMATERIALS
Volume 24, Issue 6, Pages 893-900Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(02)00420-9
Keywords
hyaluronic acid; hydrogels; photopolymerization; RGD; cell adhesion
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Hyaluronic acid (HA) was derivatized with methacrylic esters used for the preparation of hydrogels via photopolymerization. Poly(ethylene glycol) diacrylate (PEG-DA) with a molecular weight of 570 was also used as a comacromonomer to improve elastic modulus and swelling behavior. The hydrogels were readily degraded by hyaluronidase and their mechanical properties could be modulated by HA molecular weight and concentration of PEG-DA. The incorporation of RGD peptides allowed modulation of the HA properties from cell non-adhesive to adhesive. Human dermal fibroblasts were cultured on the RGD, RDG, and non-functionalized HA hydrogels for up to 7d, showing adhesion and proliferation only with incorporated RGD. (C) 2002 Elsevier Science Ltd. All rights reserved.
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