Journal
BIOCHEMICAL JOURNAL
Volume 370, Issue -, Pages 397-402Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20021853
Keywords
glutathione peroxidase; selenium transport; targeted gene disruption; thioredoxin reductase
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Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.
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