Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 55, Issue 2, Pages 181-184Publisher
ELSEVIER
DOI: 10.1016/S0939-6411(02)00196-0
Keywords
calixarenes; solid lipid nanoparticles; carbohydrates; cryoprotectants; atomic force microscopy
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In this note, we report a study of cryoprotectant carbohydrate (glucose, fructose, mannose and maltose) effects on the reconstitution of calixarene based solid lipid nanoparticle (SLN) suspensions after freeze-drying, studied by atomic force microscopy and photon correlation spectroscopy. All carbohydrates tested showed excellent cryoprotection and redispersion properties with the calixarene based SLNs. (C) 2003 Elsevier Science B.V. All rights reserved.
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