Journal
NEUROIMAGE
Volume 18, Issue 3, Pages 633-641Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1053-8119(02)00012-5
Keywords
posterior cingulate cortex; medial prefrontal cortex; area 10; event-related fMRI; shift of attention; posterior parietal cortex
Funding
- NIA NIH HHS [K23 AG000940-04, K23 AG00940-02, AG138541] Funding Source: Medline
- NINDS NIH HHS [NS30863-03] Funding Source: Medline
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The purpose of this study was to identify brain regions underlying internally generated anticipatory biases toward locations where significant events are expected to occur. Subjects fixated centrally and responded to peripheral targets preceded by a spatially valid (predictive), invalid (misleading), or neutral central cue while undergoing fMRI scanning. In some validly cued trials, reaction time was significantly shorter than in trials with neutral cues, indicating that the cue had successfully induced a spatial redistribution of motivational valence, manifested as expectancy. The largest cue benefits led to selectively greater activations within the posterior cingulate and medial prefrontal cortex. These two areas thus appear to establish a neural interface between attention and motivation. An inverse relationship to cue benefit was seen in the parietal cortex, suggesting that spatial expectancy may entail the inhibition of attention-related areas to reduce distractibility by events at irrelevant locations. (C) 2003 Elsevier Science (USA). All rights reserved.
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