Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 136, Issue 1-2, Pages 1-8Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(02)00465-4
Keywords
Chlamydia pneumoniae; human herpes virus-6; multiple sclerosis
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Funding
- NIAID NIH HHS [AI-44055, AI-44493] Funding Source: Medline
- NIAMS NIH HHS [AR-42541, AR-48331] Funding Source: Medline
- NINDS NIH HHS [NS-06985] Funding Source: Medline
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A good deal of evidence suggests an infectious component in the development of multiple sclerosis (MS) and, to date, some 20 bacteria and viruses have been associated with the disease. Recent independent sets of studies have-implicated the respiratory bacterium Chlamydia pneumoniae and human herpes virus 6 (HHV-6) in the pathogenesis of MS. However, as is the case for essentially all earlier microbial associations, experimental evidence linking either this bacterium or this virus to MS is equivocal. We review the published reports concerning involvement of C. pneumoniae and HHV-6 in MS, and data relating to possession of the APOE epsilon4 allele, which some studies indicate might influence how these or other pathogens affect disease genesis. Based on the large set of inconsistent observations available and given important new information regarding the neuropathology of MS, we contend that no conclusion is possible at this point regarding the potential role of either C. pneumoniae or HHV-6 in MS. We therefore propose future studies that should clarify whether, and if so how, these and other organisms function in the pathogenesis of this disease. (C) 2002 Elsevier Science B.V. All rights reserved.
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