Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 38, Issue 3, Pages 319-324Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0223-5234(03)00014-X
Keywords
fotemustine; nitrososulfamide; melanoma; chemoresistance
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Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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