Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy

Background. The distribution and magnitude of left ventricular hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM). Previous echocardiographic studies have focused on global left ventricular function. Recently, myocardial Doppler strain (is an element of) imaging, a newly developed technique, has allowed the quantification of regional myocardial motion. The aim of this study was to characterize regional left ventricular systolic function by myocardial Doppler is an element of imaging in patients with HCM. Methods: Included in this study were 31 patients with asymmetric septal hypertrophy and HCM, and 41 age-matched healthy patients. Regional longitudinal axial systolic is an element of was assessed at the basal, mid, and apical segments of the septal and lateral walls and compared between both groups. Results: Patients with HCM had reduced is an element of at the ventricular septum (-10.3 +/- 5.7%) compared with control patients (-19.4 +/- 3.3%, P < .001). In the HCM group, is an element of in the midseptum (-1.3 +/- 8.2%) was significantly less than at the basal (-12.2 +/- 8.7%, P < .01) and apical septum (-17.3 +/- 10.4%, P < .01), and was also less than at the midlateral wall (-9.4 +/- 5.3%, P < .05). There was a significant correlation between midseptal is an element of and intraventricular septum to posterior wall thickness ratio (r = 0.81, P < .001). Conclusion: Midseptal longitudinal is an element of was markedly decreased, even reversed in patients with HCM (paradoxic longitudinal systolic expansion), which was directly related to the degree of septal hypertrophy. Myocardial Doppler is an element of imaging could offer a unique approach to quantify regional systolic dysfunction in these patients.