Journal
PHARMACOGENOMICS
Volume 4, Issue 2, Pages 171-178Publisher
FUTURE MEDICINE LTD
DOI: 10.1517/phgs.4.2.171.22636
Keywords
complex disease; genetic association; haplotype; linkage disequilibrium; population genetics
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Funding
- NIGMS NIH HHS [GM59507] Funding Source: Medline
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Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. in this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.
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