Journal
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
Volume 16, Issue 1, Pages 59-64Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988702250585
Keywords
Lewy bodies; familial dementia; Alzheimer's disease
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Funding
- NIA NIH HHS [P50 AG05136, R01 AG018644, P50 AG005136, R01-AG18644] Funding Source: Medline
- NINDS NIH HHS [R01 NS048595] Funding Source: Medline
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The authors report a case of a 64-year-old male with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of DLB including dementia, hallucination, and parkinsonian symptoms were not apparent until late in the course of his illness. Autopsy revealed both brainstem and cortical Lewy bodies and AD pathology. Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB.
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