Journal
BRAIN RESEARCH
Volume 965, Issue 1-2, Pages 290-294Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(02)04162-8
Keywords
chronic immobilization stress; dendritic morphology; central nucleus of the amygdala; bed nucleus of the stria terminalis; anxiety
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A differential role has been suggested for two important areas in the neural circuitry of stress, central nucleus of the amygdala (CeA) and bed nucleus of stria terminalis (BNST) in the extended amygdala, in regulating fear versus anxiety. Since chronic stress enhances anxiety and consolidation of aversive memories, we examined the effects of chronic immobilization stress (CIS) on neuronal morphology in the CeA and BNST of rats. In contrast to previous reports of stress-induced atrophy in the hippocampus, CIS does not cause dendritic atrophy in CeA and BNST neurons. While dendritic arborization in CeA neurons remains unaffected, it increases in BNST neurons after CIS. These results suggest a role for dendritic remodeling of BNST neurons in stress-induced facilitation of anxiety. (C) 2002 Elsevier Science B.V. All rights reserved.
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