Journal
TETRAHEDRON-ASYMMETRY
Volume 14, Issue 5, Pages 567-576Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0957-4166(03)00019-3
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(R)- and (S)-Methadones and levo-alpha-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented. (C) 2003 Elsevier Science Ltd. All rights reserved.
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