Journal
ASIAN JOURNAL OF ANDROLOGY
Volume 16, Issue 5, Pages 669-674Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1008-682X.125412
Keywords
DNA methylation; male infertility; spermatogenesis
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Funding
- Graduate Program Cell Dynamics and Disease (CEDAD)
- International Max Planck Research School-Molecular Biomedicine (IMPRS-MBM)
- German Research Foundation (Research Unit 'Germ cell potential') [FOR 1041]
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Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described.
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