Journal
ASIAN JOURNAL OF ANDROLOGY
Volume 15, Issue 6, Pages 723-728Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.1038/aja.2013.92
Keywords
aging male; fertility outcomes; male infertility; paternal age
Categories
Funding
- Male Reproductive Health Research (MRHR) Career Development Physician-Scientist Award [K12, HD073917-01]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Program awarded
- NIH [P01HD36289]
- Eunice Kennedy Shriver NICHD
- National Institute of Kidney and Digestive Diseases [1R01DK078121]
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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.
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