Journal
SCIENCE
Volume 299, Issue 5613, Pages 1713-1716Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1080115
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Cell contact is required for efficient transmission of human T cell leukemia virus-type 1 (HTLV-1) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not understood. We show here that cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T cell physiology to allow efficient propagation between cells.
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