Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 6, Pages 2956-2961Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.6.2956
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Treatment of Th cells with compounds that elevate cAMP levels augments Th2-type lymph okine expression, in particular the synthesis of IL-5. Using primary murine CD4(+) T lymphocytes, we show in this study that inhibition of protein kinase A (PKA) activity in Th2 effector cells impairs IL-5 synthesis, whereas the expression of PKA catalytic subunit a enhances IL-5 synthesis in Th0 cells. In addition, we observed by coexpression of PKA catalytic subunit and GATA-3 in Th1 cells that the stimulatory effect of PKA is dependent on GATA-3 activity. These data demonstrate that activation of PKA in Th effector cells induces the IL-5 gene expression in a GATA-3-dependent manner.
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