Journal
CARDIOVASCULAR RESEARCH
Volume 57, Issue 4, Pages 961-973Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0008-6363(02)00714-9
Keywords
arrhythmia mechanisms; long QT syndrome; Na-channel; sudden death; ventricular arrhythmias
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Sodium ion (Na) influx through cardiac Na channels triggers the action potential in cells of the working myocardium and the specialized conduction system. Na channels thus act as key molecular determinants of cardiac excitability and impulse propagation. Na channel dysfunction may cause life-threatening arrhythmias. Here, we review the ways in which Na channel function can be aberrant due to genetic changes. We discuss how biophysical studies of mutant Na channels combined with precise clinical phenotyping may improve our understanding of Na channel function in health and disease and may be useful as a model from which to derive improved treatment strategies for common disease. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V. All rights reserved.
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