Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 6, Pages 3331-3336Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.6.3331
Keywords
-
Categories
Funding
- NEI NIH HHS [EY03040] Funding Source: Medline
- NINDS NIH HHS [NS 18146] Funding Source: Medline
Ask authors/readers for more resources
Neutrophils are the first infiltrating cell population to appear within the CNS during infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). To determine whether neutrophils play a role in limiting acute JHMV infection, mice were depleted of neutrophils. Infection of neutropenic animals resulted in increased levels of virus replication and mortality compared with control mice. Furthermore, neutropenia resulted in significantly reduced mononuclear leukocyte infiltration possibly due to reduced loss of blood brain barrier integrity during acute JHMV infection. These data suggest that infiltrating neutrophils are crucial for limiting virus replication during acute JHMV infection, contribute to the loss of blood brain barrier integrity and play a role in shaping adaptive immunity within the CNS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available