4.4 Article

Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 12, Pages 2485-2487

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00325-3

Keywords

bicyclic compounds; cyclizations; cyclopropanes; nitriles; titanium

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Here we report an easy synthesis of bicyclic primary cyclopropylamines directly from unsaturated nitriles. The described reaction involves Ti(II)-mediated intramolecular coupling of alkene and nitrile moieties. (C) 2003 Elsevier Science Ltd. All rights reserved.

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