Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 9, Issue 6, Pages 1296-1302Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200390148
Keywords
alkynes; antitumor agents; boron neutron capture therapy; carboranes; drug research; C-glycosides
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The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20 24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.
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