Low-Dose Risk Assessment for Arsenic: A Meta-Analysis Approach

We conducted a meta-analysis to explore dose-response relationships for bladder and lung cancers when people are chronically exposed to low doses of arsenic. We searched electronic databases for articles published through 2010. Ten studies on bladder cancer and ingested arsenic exposure and five studies on lung cancer and ingested arsenic exposure fit our selection criteria. We also investigate the sensitivity of the absolute risk of lung and bladder cancer under different underlying prevalence measures. Males have a higher risk of bladder cancer than do females at all maximum contamination levels. The absolute risk of bladder cancer and lung cancer from ingested arsenic correlates highly with smoking rates. For a maximum contamination level of 10 mu g/L, we estimate that there are about 2.91 additional bladder cancer cases per 100 000 people and, considering studies since 2000, we estimate that there are about 4.51 additional lung cancer cases per 100 000 people.