Journal
ORGANIC LETTERS
Volume 5, Issue 6, Pages 793-796Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0273396
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- NIGMS NIH HHS [GM 58160] Funding Source: Medline
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Graphics An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degreesC in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
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