4.8 Article

Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral Lewis acid and achiral N-oxide catalysts

Journal

ORGANIC LETTERS
Volume 5, Issue 6, Pages 949-952

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol034158a

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Enantloselective addition of TMSCN to ketones is achieved by a catalytic double-activation method using 1a-Ti(IV) complex as the Lewis acid and achiral N-oxide 2 as the Lewis base to activate ketones and TMSCN, respectively.

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