Journal
NEURON
Volume 37, Issue 6, Pages 1013-1025Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(03)00123-5
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Funding
- NIA NIH HHS [F32 AG05914] Funding Source: Medline
- NIMH NIH HHS [R21 MH066213] Funding Source: Medline
- NINDS NIH HHS [R01 NS40239] Funding Source: Medline
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fMRI was used to investigate the neural substrates supporting implicit and explicit sequence learning, focusing especially upon the role of the medial temporal lobe. Participants performed a serial reaction time task (SRTT). For implicit learning, they were naive about a repeating pattern, whereas for explicit learning, participants memorized another repeating sequence. fMRI analyses comparing repeating versus random sequence blocks demonstrated activation of frontal, parietal, cingulate, and striatal regions implicated in previous SRTT studies. Importantly, medio-temporal lobe regions were active in both explicit and implicit SRTT learning. Moreover, the results provide evidence of a role for the hippocampus and related cortices in the formation of higher order associations under both implicit and explicit learning conditions, regardless of conscious awareness of sequence knowledge.
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