Journal
FEBS LETTERS
Volume 539, Issue 1-3, Pages 56-60Publisher
WILEY
DOI: 10.1016/S0014-5793(03)00197-2
Keywords
sphingosine-1-phosphate; sphingomyelinase; ceramide; apoptosis; protein kinase B; macrophage
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Sphingosine-1-phosphate (Sph-1-P) regulates critical cellular functions including cell proliferation, differentiation, angiogenesis, and cell survival. However, its mechanisms of action are incompletely understood. Here, we show a novel biological effect of Sph-1-P: inhibition of acidic sphingomyelinase (A-SMase) activity in apoptotic bone marrow-derived macrophages. A-SMase catalyzes the conversion of sphingomyelin to ceramides, which are pro-apoptotic. This action of Sph-1-P prevents the accumulation of ceramides and blocks apoptosis, thereby promoting survival of the macrophages. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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