Journal
REGULATORY PEPTIDES
Volume 111, Issue 1-3, Pages 191-197Publisher
ELSEVIER
DOI: 10.1016/S0167-0115(02)00285-9
Keywords
sarmesin; PTZ generalized seizure model; PTZ kindling; PTZ seizure threshold; passive avoidance test; paw pressure nociceptive assay
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The present research studies the effects of sarmesin [Sar(1)Tyr(OMe)(4)] Angiotensin II (ANG II), an analogue of ANG II, on the seizure susceptibility, memory activity and nociception. It was found that this octapeptide, administered i.c.v., dose-dependently decreased the seizure intensity (pentylenetetrazol (PTZ) generalized seizure model and PTZ kindling) and augmented PTZ seizure threshold in mice. Sarmesin impaired the memory upon re-testing of rats 24 h later in the passive avoidance test. It decreased the pain threshold in a paw pressure nociceptive assay in rats. ANG II exerted pronociceptive effect as well. Taken together, these results reveal sarmesin as a behaviorally active peptide in the studied experimental animal models. (C) 2002 Elsevier Science B.V. All rights reserved.
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