Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 303, Issue 1, Pages 247-250Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0006-291X(03)00326-7
Keywords
lectin-like oxidized low-density lipoprotein receptor; single nucleotide polymorphism; coronary artery disease; oxidized LDL; myocardial infarction
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Lectin-like oxidized low-density lipoprotein receptor (LOX-1/OLR1) has been suggested to play a role in the progression of atherogenesis. We analyzed the OLR1 gene and found a single nucleotide polymorphisin (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein. We compared the group of patients with myocardial infarction (MI) (n = 102) with a group of clinically healthy subjects (n = 102), and found that the MI group had a significantly high frequency of 501G/C + 501C/C (38.2%) compared with the healthy group (17.6%; p < 0.002). The odds ratio for the risk of MI associated with the 501G/C + 501C/C genotype was 2.89 (95% CI, 1.51-5.53). These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI. Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1. (C) 2003 Elsevier Science (USA). All rights reserved.
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