Journal
SCIENCE
Volume 299, Issue 5615, Pages 2071-2074Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1080613
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- NIAID NIH HHS [AI40963-02] Funding Source: Medline
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The complete genome sequence of Enterococcusfaecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
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