Journal
ANALYTICA CHIMICA ACTA
Volume 481, Issue 1, Pages 65-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0003-2670(03)00067-9
Keywords
choline; neurotransmitters; voltammetry; biosensor; CNS
Categories
Ask authors/readers for more resources
A ceramic-based multisite microelectrode array to measure choline in vivo in brain tissues is described. The microelectrodes were linear to 200 muM choline (R-2 = 0.999 +/- 0.001) with a detection limit of approximately 0.4 muM (S/N of 3) in both single microelectrode and self-referencing amperometric recording modes. The 90% rise time of the sensor was 1.4 s, allowing for rapid measures of choline. Good selectivity (>300:1) was observed over interferents such as ascorbic acid, uric acid, and DOPAC in the single microelectrode mode. However, a self-referencing recording mode was needed to remove potassium-evoked dopamine signals in rat striatum. In vivo measurements of choline in the rat brain are presented. (C) 2003 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available