Journal
TETRAHEDRON
Volume 59, Issue 14, Pages 2477-2484Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(03)00263-1
Keywords
pyridazinones; Sonogashira coupling; chalcone
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Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed during the coupling of 1-phenyl-2-propyn-1-ol. This rearrangement afforded the E-chalcone 6 in excellent yield. (C) 2003 Elsevier Science Ltd. All rights reserved.
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