4.6 Article

Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus

Journal

BRITISH JOURNAL OF HAEMATOLOGY
Volume 121, Issue 1, Pages 139-142

Publisher

BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04233.x

Keywords

blood platelets; diabetes mellitus; cardiovascular disease; collagen; receptors; Fc

Categories

Funding

  1. NCI NIH HHS [P30 CA 14089] Funding Source: Medline
  2. NHLBI NIH HHS [HL 03740] Funding Source: Medline

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Recent clinical and laboratory observations support a potential role for the platelet FcgammaRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P < 0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.

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