Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 13, Issue 2, Pages 207-214Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(03)00014-5
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- NIGMS NIH HHS [GM65172] Funding Source: Medline
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In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.
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