Journal
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
Volume 1, Issue 2, Pages 311-316Publisher
MARY ANN LIEBERT INC PUBL
DOI: 10.1089/15406580360545125
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Funding
- Telethon [TCP00068] Funding Source: Medline
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Mutations of GPCRs can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis; others occur spontaneously in human diseases. The analysis of constitutively active GPCR mutants has attracted a large interest in the past decade, providing an important contribution to our understanding of the molecular mechanisms underlying receptor function and drug action.
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