LC-MS-MS Analysis of N,α-Diethylphenethylamine (N,α-ETH) and Its Positional Isomer N,β-Diethylphenethylamine (N,β-ETH) in Dietary Supplements

In a previous publication, we reported on the analysis of several dietary supplement/exercise formulas and the quantitation of N, alpha-diethylphenethylamine (N,alpha-ETH, 3). In this article we report on the reanalysis of these products using LC-MS-MS and GC-MS methods capable of clearly separating the N,alpha-isomer (3) from its N,beta-isomer (N,beta-ETH, 4). The reanalysis, by both methods, showed that all samples previously reported as containing N,alpha-ETH (3) do contain only that isomer with no detectable concentrations of the N,beta-ETH (4).