Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 28, Issue 4, Pages 170-173Publisher
CELL PRESS
DOI: 10.1016/S0968-0004(03)00037-9
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We describe a previously undetected domain - TRASH containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
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