Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 7, Issue 2, Pages 252-264Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(03)00019-X
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Funding
- NIGMS NIH HHS [GM-58506, GM-33894, GM-52594] Funding Source: Medline
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The (beta/alpha)(8)-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (beta/alpha)(8)-barrel containing enzymes.
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